Hull City vs Chelsea
Paul McShane is out for up to four weeks with an ankle injury sustained against Middlesbrough last weekend.
Chelsea will again be without midfielder Frank Lampard and defender Branislav Ivanovic, with the pair both likely to be absent for a month.
Lampard has a muscle injury, while Ivanovic has a knee problem.
Fantasy Player to watch : Willian
Cardiff vs West Ham
Cardiff City could hand a debut to new signing Magnus Eikrem, While Craig Bellamy may figure after two months out with knee and ankle trouble.
West Ham boss Sam Allardyce says he will make a "calculated" decision on whether to recall Andy Carroll after an eight-month absence with a foot injury.
Carroll, who last played in May, could join defender James Tomkins in returning to the Hammers side.
Fantasy player to watch : Frazer Campbell
Everton vs Norwich
Ross Barkley and Leighton Baines hope to be available for the visit of Norwich despite nursing respective toe and back injuries.
Defenders Phil Jagielka and Sylvain Distin are not expected to return from hamstring problems for another week.
Norwich have Leroy Fer back after a one-match ban, while Wes Hoolahan and Bradley Johnson return to the squad.
Michael Turner, Jonny Howson, Alex Tettey, Anthony Pilkington and Elliott Bennett are all sidelined.
Fantasy player to watch : Lukaku
Fulham vs Sunderland
Fulham are likely to be with defender Brede Hangeland after recovering from injury.
Netherlands international goalkeeper Maarten Stekelenburg could return after a four-game absence with an ankle injury.
Sunderland have no new injury concerns despite being in midweek League Cup action against Manchester United.
Gus Poyet is without long-term absentees Carlos Cuellar (thigh) and Kieren Westwood (shoulder).
Fantasy player to watch : Adel Taarabt
Southampton vs West Brom
Southampton goalkeeper Artur Boruc could make a comeback after a six-week absence with a fractured hand.
Dani Osvaldo and Victor Wanyama are absent, but Gaston Ramirez and Rickie Lambert are expected to be passed fit.
West Brom caretaker head coach Keith Downing, who takes charge for the last time before handing over to Pepe Mel, will be without defender Billy Jones.
Goran Popov is also out, while Youssouf Mulumbu and Victor Anichebe are back in training but unlikely to feature.
Fantasy player to watch : Jay Rodriguez
Tottenham vs Crystal Palace
Tim Sherwood has injury worries ahead of the visit of Palace, with Erik Lamela (thigh), Kyle Naughton (ankle, hamstring) and Roberto Soldado (calf) all doubtful. Glyfi Sigurdsson, Andros Townsend, Lewis Holtby and Jermain Defoe have also returned and could feature.
Crystal Palace manager Tony Pulis has a number of his squad carrying minor injuries and requiring fitness tests ahead of this match.
Cameron Jerome could return after missing the FA Cup win over West Brom.
Fantasy player to watch : Adebayor
Man Utd vs Swansea
Wayne Rooney has been sent for warm weather training to help quicken his recovery from a groin injury.
Jonny Evans is a fitness doubt, having been substituted with a back injury in the midweek defeat by Sunderland
Ashley Young,Nani,Phil Jones,Fellaini and Rio Ferdinand remains out.
Swansea boss Michael Laudrup is without Pablo Hernandez ,De Guzman and Roland Lamah.
Goalkeeper Michael Vorm is not yet ready to return from a knee operation.
Fantasy player to watch: Adnan Januzaj
Newcastle vs Man City
Newcastle face a defensive reshuffle as Fabricio Coloccini is out with a knee injury and Mathieu Debuchy is banned while Davide Santon remains a doubt.
Tim Krul is expected to return in goal and midfielder Yohan Cabaye looks to have overcome a recent Achilles injury.
Manchester City have Yaya Toure, Jesus Navas and Micah Richards available after recent injuries.
Leading scorer Sergio Aguero (calf) is still a week or so away from returning, while Stevan Jovetic and Jack Rodwell also remain sidelined.
Fantasy player to watch : Edin Dzeko
Stoke vs Liverpool
Oussama Assaidi is ineligible against his parent club, while Jack Butland could be named in goal with Asmir Begovic and Thomas Sorensen injured.
Defender Robert Huth is unlikely to be rushed back from knee surgery.
Liverpool defender Daniel Agger is expected to be out for four weeks with a calf injury picked up against Oldham Athletic in the FA Cup.
Daniel Sturridge has overcome a sprained ankle and Mamadou Sakho could return after a hamstring problem.
Fantasy player to watch : WHO ELSE! Luis Suarez !
Aston Villa vs Arsenal
Ciaran Clark will return to bolster Villa's defence against Arsenal after serving a suspension against Sunderland.
Nathan Baker and Ron Vlaar who will require late tests after missing out in the cup with hamstring and calf issues.
Theo Walcott is sidelined for the rest of the season with the knee injury while Aaron Rasmey remains out.
Olivier Giroud and Ozil are available while Vermaleen and Gibbs remains doubt for the Villa game.
Fantasy player to watch : Santi Cazorla
I am currently on Davis/Riise/Kompany/Baines/Taarabt/Januzaj/Ozil/Eriksen/Lukaku/Berbatov/Suarez (c)
Bench : Marshall/Rosicky/Turner/Reid