Manchester United will be without Nani and Antonio Valencia due to injury but Paul Scholes returns from suspension. Rio Ferdinand may also return which means one of Jonny Evans and Chris Smalling could miss out and Anderson has probably done enough to earn himself another start.
Sir Alex Ferguson has a number of attacking options with Ashley Young, Danny Welbeck, Wayne Rooney, Javier Hernandez and Robin van Persie all available so it's difficult to predict exactly who starts and who gets a rest. However, United have already won their Champions League group so it would make sense for Rooney and RvP to play against Reading and then sit on the bench for the visit of Cluj.
Reading's Jimmy Kebe remains a major doubt but Danny Guthrie should be available following a thigh problem. Alex McCarthy remains sidelined so Adam Federici will continue in goal.
Chelsea will once again be without John Terry and Frank Lampard due to injury and Daniel Sturridge remains sidelined due to a troublesome hamstring so Fernando Torres will continue to lead the line in search of his first league goal in almost 11 hours of football.
West Ham will have midfielder Mark Noble back from suspension but Andy Carroll is a doubt with a knee injury. If he fails to prove his fitness he could be replaced by Carlton Cole.
Manchester City midfielder James Milner will miss the weekend fixture with a hamstring injury, while Jack Rodwell, Gael Clichy and Micah Richards are also out injured but Samir Nasri is available for selection. Mario Balotelli is being tipped to start after his goal in midweek and Carlos Tevez is well rested, but the Mancini-Striker-Lottery really isn't worth playing with so many alternative striking options available for fantasy managers.
Everton have concerns over the fitness of Leighton Baines but David Moyes will give him "every chance" to prove he's ready. If not, Bryan Oviedo is the man set to replace him. Kevin Mirallas is training again but is unlikely to be risked while Nikica Jelavic has been suffering with illness and will face a late fitness test. Victor Anichebe and Seamus Coleman are out.
Arsenal's Bacary Sagna is doubtful with a foot injury so could be replaced by Carl Jenkinson. Lucas Podolski should return but Laurent Koscielny is set for a spell on the sidelines with a thigh injury and Andre Santos is out so Kieran Gibbs will start at left-back. In-form Theo Walcott has an ankle knock but is expected to recover and start the match.
Swansea's Pablo Hernandez is sidelined with a thigh injury picked up in midweek but Chico should be available after a shoulder problem. Danny Graham is still suffering with a virus so Michu will continue upfront with Wayne Routledge likely to be in support after his 2 goals in against West Brom.
Liverpool welcome back Lucas Leiva after a three-month injury absence but it remains to be seen if he's ready to start or will take his place on the bench. Joe Cole is fit after a hamstring complaint and Andre Wisdom could come back into contention for a start, while Jose Enrique should continue on the left wing.
Southampton have no new injuries to contend with although Nigel Adkins must decide if he sticks with error-prone keeper Paulo Gazzaniga. Defender Danny Fox could return from a knee complaint.
Newcastle will be without utility man James Perch after he picked up his fifth yellow card of the season in midweek. Steven Taylor, Hatem Ben Arfa, Gabriel Obertan, Yohan Cabaye and Shola Ameobi are all sidelined through injury so bargain filler Shane Ferguson could start.
Wigan's Gary Caldwell and David Jones are rated 50/50 due to injury while Albert Crusat, Ben Watson, Ryo Miyaichi, Shaun Maloney, Antolin Alcaraz and Ivan Ramis are all out. This could mean another start for Adrián López Rodríguez aka Piscu, although it is dependant on Caldwell's recovery of lack of it.
Norwich will have Mark Bunn in goal after John Ruddy was ruled out for 3 months after thigh surgery but Chris Hughton has no other injury concerns.
Sunderland captain Lee Cattermole is out after he suffered knee ligament damage so Jack Colback will replace him. Matt Kilgallon is likely to continue at centre-back with John O'Shea out with a calf injury.
QPR keeper Julio Cesar is rated doubtful so Rob Green will continue to deputise if he fails to recover. Bobby Zamora and Andrew Johnson are both out so either Adel Taarabt or Esteban Granero will be pushed up in support of Djibril Cisse. Harry Redknapp could keep the same defensive line-up that kept a clean sheet at Sunderland meaning Fabio and Anton Ferdinand would sit on the bench again.
Aston Villa's Enda Stevens has been ruled out with injury so Eric Lichaj is set to replace him at left-back. Captain Ron Vlaar remains a major doubt with a calf problem so Nathan Baker should start in the center of defence and England international Darren Bent is likely to miss out again as he and Paul Lambert continue their mysterious falling out.
Fulham are still without Brede Hangeland through suspension while Mladen Petric could replace Hugo Rodallega. Bryan Ruiz, Alex Kacaniklic and Kieran Richardson are all out with injuries.
Tottenham's Emmanuel Adebayor is still suspended but Steven Caulker returns from the illness that kept him out of the midweek match against Liverpool. Scott Parker and Younes Kaboul are back in light training but won't be considered for first team action until mid-to-later December. Benoit Assou-Ekotto remains on the treatment table.
West Brom's Zoltan Gera should be fit for West Brom after a groin problem kept him out in midweek and Boaz Myhil will continue in goal for the foreseeable future after Ben Foster underwent surgery on his groin earlier in the week.
Stoke will be without Peter Crouch after a horrific injury suffered in midweek (losing 3 teeth in the process) so Neal's mate Kenwyne Jones is likely to replace him.
That's it for now but it's still quite early in the afternoon so I'll add any additional news as I hear / read about it.
My current Yahoo team is ...
Lloris, Lichaj, Vertonghen, Shorey, Sterling, Routledge, Cazorla, Granero, Giroud, Suarez, van Persie
However – I am considering dumping van Persie and using the funds to completely reinvent my team as I attempt to kick-start my fantasy season.
How are things looking for you?