This is what I settled on in the end, a rarely used 4-3-3 with 9 double gamers from Chelsea and Reading, plus my hunch Mark Noble and Carlos Tevez to ensure I had a Manchester City representative against Southampton after bottling spending 19+ on Sergio Aguero
On the barndoor (where you buy players for next week before their values adjust) I would be looking at Tottenham at home to West Bromwich Albion and Manchester United at home to Fulham.
Good luck to everyone, let me know what you ended up with the comments section below. Cheers!