Let's start with the big news, which is Wayne Rooney's likely absence for Manchester United's trip to QPR. Sir Alex Ferguson has classed Rooney as 'very unlikely' to be fit enough after a sinus infection (despite starting training again today) which means Robin van Persie is pretty much certain to start .
Who partners RvP? Toss a coin between Danny Welbeck and Javier Hernandez. Meanwhile, Phil Jones and Paul Scholes are both missing but Nani could earn a rare league outing after impressing in the FA Cup, while Tom Cleverley and Shijni Kagawa are both likely to feature.
Arsenal will be looking to bounce back at home to Aston Villa and Carl Jenkinson will be hoping for a recall to replace the injured Bacary Sagna, while Olivier Giroud should start upfront after he was benched for that Champions League defeat to Bayern Munich.
Nacho Monreal - who was cup tied - will return to the starting line-up meaning one of the central defenders will be benched. I'd expect this to be Lauren Koscielny as Per Mertesacker's heigh could come in handy against the dangerous Christian Benteke.
Manchester City could be without captain Vincent Kompany and Gareth Barry this weekend, while Micah Richards is still out with a knee injured.
Chelsea's Frank Lampard and Branislav Ivanovic should return to the starting XI after they earned a rest in the Europa League tie in midweek, while Demba Ba should replace Fernando Torres who played 90 minutes.
Newcastle keeper Tim Krul is a doubt after injuring his ankle last night and Yoan Gouffran is also struggling to recover from the gashed leg he picked up almost two weeks ago.
Tottenham's Jermain Defoe is still out so Emmanuel Adebayor will continue as the loan front-man for the trip to West Ham on Monday night.
Everton could be without striker Victor Anichebe which could mean a Premier League recall for Nikica Jelavic, but Seamus Coleman is back in training so the Toffees have a near-fully fit squad available for David Moyes to choose from.
Fulham's Kieran Richardson will miss the visit of Stoke despite nearing a return from a calf injury but Sascha Riether is back in the squad.
For Stoke, Brek Shea and defender Marc Wilson have recovered from long-term injuries and are both named in the squad. Cameron Jerome has overcome a knee problem, but Michael Owen is a doubt with yet another injury.
Harry Redknapp has been telling us all that Loic Remy's injury was nowhere near as bad as first reported, and yet the striker is still listed as a big doubt for this weekend.
West Brom manager Steve Clark could recall Peter Odemwingie to the squad but the majority of press outlets are putting Romelu Lukaku as the starting striker this weekend.
Grant Holt should return for Norwich.
That's most of the important news covered, but I'll add to it later if anything else takes my fancy.
My current team is:
Lloris, Kelly, Debuchy, Monreal, Holtby, Cazorla, Akpan, Walcott, Gouffran, Lukaku, van Persie
I have obvious concerns over Gouffran for the reason listed earlier in the post so there may need to be a re-jig before the deadline but I'll wait for the price-changes tomorrow morning. I'm keen to fit Nani in somewhere if I can and I have a "Funny Friday Feeling" for Paul Scharner, so he could replace Hope Akpan. The rest should stay as it is.
How's your team looking?