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Manchester City's striker crisis sees them start a match without Sergio Aguero, Edin Dzeko or Stevan Jovetic for the first time in recent memory. With 18-year-old Jose Pozo not overly impressive leading the line on his own, Manuel Pellegrini has opted to start with a false nine setup, with Samir Nasri, David Silva and James Milner the most advanced as the Citizens take on Crystal Palace.
Following the early match, we'll see who emerges victorious between Tottenham Hotspur and Burnley, see if West Ham can compound Leicester City's misery, watch Southampton's attempt to stop their 4-match losing streak against Everton, see if Charlie Austin's return can inspire a Queens Park Rangers victory over West Bromwich Albion, find out if David De Gea's heroics will play a part again as Manchester United take on Aston Villa, and discover whether Swansea's poor away form will be enough to see Hull City pick up a point or three.
For my fantasy team, I've struggled mightily this season, so I've opted to go for a few differentials because I don't have much else to lose at this point! Here's where I settled:
David De Gea, Kyle Walker, Phil Jones, Aaron Cresswell, Christian Eriksen, David Silva, Stewart Downing, Lazar Markovic, Harry Kane, Andy Carroll, Wilfried Bony
How did your team end up? Who are you banking on this weekend? Good luck as always, and let's chat!