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Out: Fantasy-relevant players who have been confirmed out for the week, either through injury or suspension
Doubt: Players facing the dreaded fitness test, rotation concerns and those who are out of form/favor
In: The likeliest replacements for the Outs & Doubts or those returning from injury
Win: Fantasy player to watch / my hunch pick of the week
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Out: Mikel Arteta, Francis Coquelin, Theo Walcott, Jack Wilshere
Doubt: Joel Campbell, Alex Oxlade-Chamberlain, Alexis Sanchez
In: Mathieu Flamini, Aaron Ramsey
Win: Mesut Ozil
With doubts over the fitness of Alexis Sanchez and a number of other Gunners, it will be up to the German maestro to do his thing yet again. Thankfully for Arsenal, Ozil's form has been consistently great all season.
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Out: Jordan Amavi, Jack Grealish, Tiago Ilori
Doubt: Gabriel Agbonlahor, Idrissa Gana Gueye
In: Carlos Sanchez, Scott Sinclair
Win: Alan Hutton
Hutton should be a guaranteed starter in the Villa backline now that Amavi has been ruled out for the season, and the Scot is always good for some attacking returns even if Villa fail to keep a clean sheet.
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Out: Max Gradel, Tyrone Mings, Callum Wilson, Tommy Elphick
Doubt: Christian Atsu, Artur Boruc, Marc Pugh, Tokelo Rantie, Lee Tomlin
In: Andrew Surman
Win: Matt Ritchie
The Cherries have a tough task ahead of them this weekend, facing off against a red-hot Everton side. Attacking players seem the safer bet from Bournemouth this week, and Ritchie has the most potential to put up a big score.
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Out: Thibaut Courtois, Radamel Falcao
Doubt: John Terry, Ramires, Kenedy
In: Gary Cahill, Cesar Azpilicueta
Win: Eden Hazard
Last season's player of the year is finally showing signs of returning to some semblance of form. He's scored in his last three meetings against Spurs, so it wouldn't be surprising to see the Belgian on the scoresheet again this weekend.
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Out: Dwight Gayle, Bakary Sako
Doubt: N/A
In: Wilfried Zaha
Win: Yohan Cabaye
With an ever-rotating cast of characters ahead of him, Cabaye is the most assured starter in the Palace attack, and has been the most consistent points earner as well. No sense in avoiding a good thing.
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Out: Phil Jagielka, Luke Garbutt, Bryan Oviedo
Doubt: Leighton Baines, Tyias Browning
In: N/A
Win: Arouna Kone
The impressive attacking performances at Everton seem to be on a rotation, so it should be Kone's week on current evidence. Call it a hunch.
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Out: N/A
Doubt: N/A
In: N/A
Win: Jamie Vardy
With the record on the line this week, could it be anyone else?
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Out: Lucas (suspended), Daniel Sturridge, Jordan Henderson, Mamadou Sakho, Joe Gomez, Danny Ings
Doubt: Philippe Coutinho
In: James Milner, Christian Benteke, Joe Allen
Win: Roberto Firmino
Firmino has flourished under Jurgen Klopp, and should be a guaranteed starter this week against Swansea. Depending on the availability of Coutinho, he could even start as the lone striker again. In any case, he's in great form and will look to build on his impressive performance against Man City from last weekend.
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Out: Joe Hart, Vincent Kompany, Eliaquim Mangala, Samir Nasri, Pablo Zabaleta
Doubt: Gael Clichy, Jesus Navas, Fernando (all rotation)
In: Willy Caballero, Nicolas Otamendi, Aleksandar Kolarov, David Silva
Win: Sergio Aguero
The return of David Silva is a huge deal for City after seeing Aguero return last week. The dynamic duo should be too much for the Saints to handle, and with a couple extra matches under his belt Aguero's fitness should be sharper than in his goalscoring return against Liverpool in Week 13.
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Out: Michael Carrick, Ander Herrera, Phil Jones, Luke Shaw, Antonio Valencia
Doubt: Matteo Darmian, Memphis Depay (both selection)
In: Anthony Martial, Wayne Rooney, Marcos Rojo
Win: Juan Mata
With question marks over who starts between Memphis and Jesse Lingard, Martial just returning to fitness and Rooney still not delivering for his club, Mata is the best bet for returns against league-leaders Leicester.
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Out: Tim Krul
Doubt: Cheikh Tiote
In: Vurnon Anita
Win: Moussa Sissoko
Newcastle are misfiring and need an inspirational performance from an experienced player, and I think Sissoko will step up this week. Palace are very attack-minded down the left flank, so Sissoko should have some freedom on the right flank with Darryl Janmaat.
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Out: Gary Hooper, Alexander Tettey, Matt Jarvis
Doubt: Andre Wisdom, Nathan Redmond (both rotation)
In: Russell Martin, Wes Hoolahan
Win: Robbie Brady
The Canaries will find things tough against Arsenal, but Brady has been delivering consistent points from both sides of the ball and will be key to Norwich finding any success in this match.
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Out: Graziano Pelle (suspended), Jay Rodriguez
Doubt: N/A
In: Sadio Mane, Shane Long
Win: Sadio Mane
Without Pelle in the lineup, the attacking impetus will shift to the midfield for the Saints. Mane doesn't usually play after the International Break, so he should be restored to the starting lineup this weekend fresh and ready to go against Man City.
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Out: Marc Muniesa
Doubt: Phillip Wollscheid
In: Geoff Cameron (maybe)
Win: Erik Pieters
Stoke have been very solid in defense recently, and both fullbacks have been in good form as well. With Johnson scoring last week, I'll give Pieters the vote of confidence to contribute against Sunderland this time out.
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Out: Billy Jones (suspended)
Doubt: Jermain Defoe, Fabio Borini
In: DeAndre Yedlin, Adam Johnson (maybe)
Win: Patrick van Aanholt
It's been a long time since we've been able to call PvA a fantasy favorite, but with little competition for his spot this week he seems a safe starter. A home match following a confidence-boosting win against Crystal Palace may be just what he needs to remind us why he was such a popular choice last season.
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Out: Jonjo Shelvey (suspended)
Doubt: Leon Britton, Wayne Routledge (both rotation), Bafetimbi Gomis (form)
In: Jack Cork
Win: Andre Ayew
With the strikers at Swansea failing to inspire, there's been talk that Ayew may be given the role from the start against Liverpool. Even if he doesn't, though, the new signing has been the brightest spark for the Swans this season and should cause the Reds backline some discomfort.
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Out: Dele Alli (suspended), Nacer Chadli
Doubt: Nabil Bentaleb, Erik Lamela
In: Ryan Mason
Win: Harry Kane
He's back and can't stop scoring at the moment. Given he scored a hat-trick against Chelsea when they were title winners last campaign, the prospect of facing the Blues shouldn't be intimidating for the England man, especially considering their current predicament.
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Out: Sebastian Prodl
Doubt: Valon Behrami, Jurado
In: Nathan Ake
Win: Heurelho Gomes
Aston Villa were abject in defeat against Everton, and I don't expect them to find much more joy against a very good Watford side. Gomes has been the anchor of the defense for the Hornets, and I like his chances of a clean sheet this weekend.
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Out: Chris Brunt (suspended)
Doubt: N/A
In: Gareth McAuley
Win: Stephane Sessegnon
Tony Pulis has restored his faith in Sessegnon in recent weeks and has been rewarded with some promising performances. A breakout is on the horizon for the attacking midfielder, and I have a feeling this is the week he delivers against a depleted West Ham squad.
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Out: James Collins (suspended), Mark Noble (suspended), Dimitri Payet, Enner Valencia
Doubt: Andy Carroll (selection)
In: Mauro Zarate, Alex Song (maybe)
Win: Manuel Lanzini
We're starting to run out of reliable options to choose from a team that started the season so brightly. Injuries and suspensions have ravaged the starting lineup for the Hammers, though Lanzini has been a bright light shining in the darkness that is life without Dimitri Payet.
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Has this injury news affected your plans for this weekend? Are there any slight doubts you're still considering for your team? Share your thoughts and questions in the comments!