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Below is a breakdown of what each of the categories means:
Out: Fantasy-relevant players who have been confirmed out for the week, either through injury or suspension
Doubt: Players facing the dreaded late fitness test, rotation concerns and those who are out of form/favor
In: The likeliest replacements for the Outs & Doubts
Win: Fantasy player to watch / my hunch pick of the week
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Out: Mathieu Debuchy, Aaron Ramsey, Jack Wilshere, Mikel Arteta
Doubt: Danny Welbeck (rotation), Kieran Gibbs (form), David Ospina (form)
In: Theo Walcott (maybe), Alex Oxlade-Chamberlain (maybe), Wojciech Szczesny
Win: Olivier Giroud
After the demoralizing defeat against Monaco in the Champions League, the Gunners should be out for revenge against in-form Everton. Look to the attackers to put up points here, but avoid the questionable defense.
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Out: Ron Vlaar (suspended)
Doubt: Nathan Baker, Alan Hutton, Philippe Senderos, Aly Cissokho (maybe)
In: Jores Okore, Matthew Lowton, Leandro Bacuna (maybe)
Win: Christian Benteke
A bright start last week ended in another crushing defeat, but Villa did look better in Tim Sherwood's first match in charge. They could put some points on the board traveling to face the less than full-strength Geordies.
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Out: Dean Marney, Matt Taylor, Kevin Long
Doubt: N/A
In: N/A
Win: Danny Ings
A vital home match against Swansea is a big opportunity to put up 3 points. Danny Ings has been in excellent form at Turf Moor, and you shouldn't bet against that continuing this weekend.
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Out: Frazier Campbell, Marouane Chamakh, Yaya Sanogo
Doubt: Jordon Mutch (rotation)
In: Mile Jedinak (maybe)
Win: Jason Puncheon
With their usual strike force unavailable through injury, the attacking onus should fall to the wide men, and Puncheon has been in good form. He could also be on penalty duty if Mile Jedinak doesn't get the start.
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Out: Aiden McGeady, Stephen Pienaar, Christian Atsu, Bryan Oviedo
Doubt: Mohamed Besic
In: Gareth Barry, Darron Gibson (maybe)
Win: Romelu Lukaku
The troll king is back to haunt us again. After 5 goals in two Europa League matches against Young Boys, can he keep his hot goal scoring form going against Arsenal? Expect to be upset whichever decision you make.
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Out: James Chester, Mohamed Diame, Liam Rosenior, Robert Snodgrass
Doubt: N/A
In: N/A
Win: Dame N'Doye
Two starts, two goals for the Tigers' new front man. N'Doye has struck up a great partnership with Nikica Jelavic, and both look to be among the best options for a Hull side that doesn't defend well on the road.
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Out: Lucas Leiva, Steven Gerrard, Jon Flanagan
Doubt: Daniel Sturridge (fatigue), Jordan Ibe (rotation), Jordan Henderson, Mamadou Sakho
In: Adam Lallana, Lazar Markovic, Dejan Lovren (all maybe)
Win: Philippe Coutinho
The penalty kick loss to Besiktas after extra time on Thursday, plus the travel time back from Turkey, mean Liverpool go into their very difficult matchup against City on one leg. Coutinho was rested midweek and will need to be at his best to inspire the Reds to victory.
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Out: Matija Nastasic
Doubt: Aleksandar Kolarov, Edin Dzeko (both rotation)
In: Gael Clichy, Wilfried Bony (maybe)
Win: Sergio Aguero
With an extra couple days of rest and a deeper squad to choose from, City look to be set up well to succeed, even on the road at Anfield. Sergio Aguero is among the top 5 players in the league when on form, and you wouldn't bet against him claiming pole position in the Golden Boot discussion this weekend.
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Out: Robin van Persie, Michael Carrick
Doubt: Patrick McNair, Luke Shaw (both rotation)
In: Ashley Young, Antonio Valencia (both maybe)
Win: Wayne Rooney
With RVP sidelined through injury, we should see Rooney restored to his rightful place at the top of the pitch. He'll also claim penalty duty and may even take some free kicks. He's been in poor form, but a home match against the Black Cats should provide a great stage for the England man to get his season back on track.
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Out: Jack Colback (suspended), Remy Cabella, Paul Dummett, Cheikh Tiote
Doubt: Yoan Gouffran (rotation)
In: Masadio Haidara, Mehdi Abeid, Vurnon Anita, Sammy Ameobi (maybe)
Win: Ayoze Perez (hunch)
The Magpies were dire against Man City last game week, and don't look to be in much better shape heading into their match against Villa. Colback, Cabella and Tiote will all be missed for the qualities they add to the side, so it'll be up to the strikers to lead the way.
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Out: Toby Alderweireld, Jay Rodriguez
Doubt: Matt Targett, Filip Djuricic, James Ward-Prowse, Steven Davis (all rotation)
In: Ryan Bertrand, Sadio Mane, Dusan Tadic, Morgan Schneiderlin
Win: Sadio Mane
With Graziano Pelle misfiring, the midfield looks like the best place to invest for the Saints. The tricky Sadio Mane should be restored to the starting lineup if he can show up on time, but Bertrand's return from suspension also makes him a strong option.
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Out: Bojan Krkic, Ryan Shawcross, Marc Muniesa
Doubt: Peter Crouch (selection)
In: Erik Pieters
Win: Victor Moses
Stoke are such a strange proposition this season that it's hard to know whether investing in their defense, even against goal-shy Hull, is worthwhile. That leaves the attackers as the de facto picks for the week, and Moses offers the most potential for investment among them.
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Out: Billy Jones, Emmanuele Giaccherini, Jack Rodwell
Doubt: Will Buckley, Danny Graham (rotation), Patrick van Aanholt (rotation)
In: Jermain Defoe, Conor Wickham (maybe), Anthony Reveillere (maybe)
Win: Jermain Defoe
Defoe is expected to come straight back into the starting lineup after missing the last couple matches through injury. He'll need to have his shooting boots on if he's going to trouble the United back line, but it's hard to see where else the goals will come from at the moment.
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Out: Kyle Bartley
Doubt: Modou Barrow, Leon Britton (rotation)
In: Jack Cork
Win: Wayne Routledge (hunch)
I still maintain that Bafetimbi Gomis is one of the worst starting strikers in the league. The Wilfried Bony money should have gone into buying a classy striker, but as it is the Frenchman still leads the line. He'll need support from elsewhere, and Routledge was pushed up into a forward role last time out.
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Out: Graham Dorrans
Doubt: Saido Berahino, Victor Anichebe, James Morrison
In: Callum McManaman, Stephane Sessegnon (maybe)
Win: Brown Ideye
With doubts over Berahino's starting status, the attacking threat will need to come from Ideye through the center. Southampton pose enough of an attacking threat that investment in the Baggies defense is probably ill-advised, though Tony Pulis does have them much better organized since he took over.
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Out: Morgan Amalfitano (suspended) Andy Carroll, Carlton Cole, Modibo Maiga
Doubt: Mark Noble (rotation)
In: Kevin Nolan (maybe)
Win: Diafra Sakho
Much like Danny Ings, Sakho is a home-crowd hero. With Andy Carroll out through injury, he'll be the focal point of a West Ham attack that should get plenty of chances against the Eagles.
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Has the injury news changed any of your decisions? For me, doubts over Walcott's starting status mean I'm weighing my options between Danny Ings and Diafra Sakho to join Wayne Rooney in my attack. I've got Harry Kane on the bench at 9.42 in preparation for Spurs' double week next week, so am limited to just the two strikers. Here's where I'm at so far:
Heaton
Trippier, Wollscheid, Cresswell
Moses, Sinclair, Di Maria, Downing, Walcott
Rooney, Sakho
Bench: Okore, Upson, Kane, Schwarzer
How are your teams shaping up? Have you settled on your final 11 or are you still tinkering like me?