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Out: Fantasy-relevant players who have been confirmed out for the week, either through injury or suspension
Doubt: Players facing the dreaded fitness test, rotation concerns and those who are out of form/favor
In: The likeliest replacements for the Outs & Doubts
Win: Fantasy player to watch / my hunch pick of the week
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Out: Tomas Rosicky, Danny Welbeck, Jack Wilshere
Doubt: Laurent Koscielny, Per Mertesacker
In: Gabriel Paulista
Win: Alexis Sanchez
After a disappointing 0-0 draw to Liverpool last week, this is the match for Arsene Wenger's side as they take on Newcastle as they desperately need the three points to maintain themselves in the title race.
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Out: Jores Okore
Doubt: Adama Traoré
In: Scott Sinclair
Win: Jordan Amavi
New man Traore will be a doubt for Tim Sherwood's men against Sunderland over the weekend in a tough test for both sides, however Jordan Amavi might be the man needed to try and achieve the three points.
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Out: Harry Arter
Doubt: Kermorgant, Smith
In: N/A
Win: Callum Wilson
Bournemouth had an amazing match last week against West Ham when Callum Wilson scored a hat trick against the Hammers. Can he do it again against Leicester? Two surprising sides so far in the new season.
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Out: John Terry (suspension)
Doubt: Oscar (calf), Baba Rahman (fitness)
In: Willian, Kurt Zouma
Win: Pedro
Chelsea finally got their first win in the Premier League this season away at West Brom with goals coming from three Spanish internationals. Can they do it against Crystal Palace next week? My safe bet is that Zouma will go in for Terry and fit in well while Pedro is looking for another great match just like his debut.
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Crystal Palace
Out: Frazier Campbell , Mile Jedinak, Patrick Bamford (ineligible)
Doubt: Yannick Bolasie, Marouane Chamakh (both match fitness), Dwight Gayle, Wilfried Zaha (both calf), Julian Speroni (finger), Connor Wickham (ribs)
In: N/A
Win: Yohan Cabaye
The Eagles will have to look for a miracle in their match against their London rivals, but Cabaye has the quality to unlock defenses.
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Out: Darron Gibson, Brendan Galloway, Leighton Baines, Tony Hibbert
Doubt: N/A
In: Tyias Browning
Win: Romelu Lukaku
Roberto Martinez's men will look for a good result against Spurs when Lukaku will look to be instrumental.
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Leicester City
Out: Matty James, Paul Konchesky
Doubt: N/A
In: N/A
Win: Riyad Mahrez
Can Leicester City keep up its amazing start? Bournemouth will be a test but if Mahrez can continue to score goals, they should do alright.
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Liverpool
Out: Joe Allen, Daniel Sturridge, Adam Lallana, Jon Flanagan
Doubt: Jordan Henderson
In: Roberto Firmino
Win: Christian Benteke
West Ham will be a tough test for the Reds. Brendan Rodgers' side will need to rely on the Belgian striker to get the goals.
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Out: Wilfried Bony, Fernando, Pablo Zabaleta, Gael Clichy
Doubt: Eliaquim Mangala (rotation)
In: Nicolas Otamendi (maybe)
Win: Sergio Aguero
City are undefeated and have not conceded a goal yet in the new season. The match against Watford should be an easy test to maintain that unbeaten record, and you have to think Aguero will be involved.
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Out: David De Gea, Adnan Janzuaj, Phil Jones
Doubt: Marcos Rojo
In: Ander Herrera
Win: Wayne Rooney
Rooney scored in Europe, but can he do it in the Premier League? I like his chances this week.
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Newcastle United
Out: Sylvain Marveaux, Emmanuel Riviere
Doubt: Moussa Sissoko
In: Florian Thauvin
Win: Georginio Wijnaldum
Tough test against Arsenal but Steve McClaren's men have the capability to see off the Gunners, if Wijnaldum and the card-happy Mitrovic can do something about it.
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Out: Youssuf Mulubu, Martin Olsson, Lewis Grabban (suspended)
Doubt: N/A
In: N/A
Win: Steven Whittaker
A tough match for Norwich where their amazing run so far might go to an end against the Saints. The defenders have been scoring goals for the Canaries, so maybe they can do that again this week.
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Out: Jordy Clasie, Ryan Bertrand, Fraser Forster, Florin Gardos, Gaston Ramírez
Doubt: Victor Wanyama
In: N/A
Win: Graziano Pellé
After going out of the Europa League, Ronald Koeman's men can now focus on the league in a big match against Norwich. Pelle will lead the line and should get plenty of chances to score.
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Out: Peter Odemwingie, Ryan Shawcross
Doubt: N/A
In: N/A
Win: Xherdan Shaqiri
The Swiss wonderkid will look to have another amazing match against a West Brom side who haven't been as convincing.
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Sunderland
Out: Jordi Gómez, Adam Matthews, Adam Johnson
Doubt: Ola Toivonen, Stephen Fletcher (rotation)
In: Danny Graham
Win: Jermain Defoe
The Black Cats will have to rely on Defoe against the side from the Midlands to pick up points.
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Swansea
Out: N/A
Doubt: N/A
In: N/A
Win: Jefferson Montero
The Ecuadorian has been in fine form for Garry Monk's side but can they see off Manchester United like they did at the beginning of the season last year in Van Gaal's debut?
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Out: Christian Eriksen
Doubt: Andros Townsend, Heung Min-Son (work permit)
In: Ryan Mason
Win: Harry Kane
Harry Kane will need to score to take away the pressure, simple as that.
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Out: Lloyd Doyley, Joel Ekstrand, Miguel Britos (suspended)
Doubt: Almen Abdi
In: Alessandro Diamanti
Win: Troy Deeney
Manchester City are a tough test, but if any team can achieve something on an upset, it's them. Deeney will be instrumental to their chances.
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Out: Ben Foster
Doubt: Chris Brunt, Callum McManaman
In: Serge Gnabry
Win: Salomon Rondon
Rondon, the new transfer will look to keep Stoke City at bay.
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Out: Adrian (suspended), Andy Carroll, Enner Valencia, Mauro Zarate
Doubt: Reece Oxford, O'Brien
In: Darren Randolph, Modibo Maiga, Pedro Obiang
Win: Dimitri Payet
Can the replacement of Adrian help the Hammers to a victory against Liverpool? The Frenchman Payet will have to be in top form.