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Out: Fantasy-relevant players who have been confirmed out for the week, either through injury or suspension.
Doubt: Players facing the dreaded fitness test, rotation concerns and those who are out of form/favor.
In: The likeliest replacements for the Outs & Doubts.
Win: Fantasy player to watch / my hunch pick of the week.
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Out: Tomas Rosicky, Danny Welbeck, Jack Wilshere
Doubt: Per Mertesacker, Olivier Giroud (selection)
In: Gabriel Paulista, Theo Walcott
Win: Alexis Sanchez
With a clean sheet unlikely for the Gunners now that Chelsea are back to scoring ways, the attack will need to step up to get a result at Stamford Bridge. Alexis Sanchez is the man for the big occasion, and should cause the Blues' center back pairing issues, however they decide to line up.
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Out: Jores Okore
Doubt: Jose Angel Crespo, Carles Gil, Idrissa Gueye, Adama Traore, Tiago Ilori
In: Jack Grealish
Win: Joleon Lescott
Just a few weeks removed from his deadline-day move, the former West Brom defender faces his old club. He should be settled in defense next to fellow ex-Man City defender Micah Richards, and will be integral to Villa's hopes of erasing the heartbreaking loss to Leicester in Week 5.
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Out: Harry Arter, Max Gradel, Tyrone Mings
Doubt: Charlie Daniels, Christian Atsu
In: Adam Smith, Junior Stanislas, Glenn Murray (maybe)
Win: Callum Wilson
We've seen on one occasion already this season that Wilson has the potential to have a Charlie Austin-type season for the Cherries. This match is a good opportunity for him to show why he's drawing those comparisons.
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Out: Thibaut Courtois, Willian
Doubt: Oscar, Pedro, Branislav Ivanovic (selection), Gary Cahill (rotation)
In: John Terry, Abdul Baba Rahman (maybe)
Win: Diego Costa
With question marks over the form and/or fitness of a number of players, the impact of Diego Costa will be key to Chelsea's hopes to get Arsenal back for their Community Shield victory to begin the season. He scored in this fixture last season, and I think he'll do it again this time around.
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Out: Marouane Chamakh, Joel Ward
Doubt: Damien Delaney, Joe Ledley, Connor Wickham
In: Brede Hangeland, Martin Kelly
Win: Jason Puncheon (hunch)
It's been all about new-boys Bakary Sako and Yohan Cabaye at Palace this season, but the old veteran gets the nod in my mind. I think we could be in line for another special set piece from Puncheon, whether that is in the form of a goal or an assist against Spurs.
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Out: Leighton Baines, Tom Cleverley, Darron Gibson, Steven Pienaar
Doubt: Mohamed Besic, Seamus Coleman
In: Ramiro Funes Mori (maybe)
Win: Ross Barkley
Barkley's form this season has turned plenty of heads, and you have to think fans of nearly all Premier League teams would love to be able to call on him for their matchday squads. His directness may be the key to breaking down a composed Swansea defense.
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Out: Matty James
Doubt: Marc Albrighton (selection)
In: Nathan Dyer (maybe)
Win: Riyad Mahrez
It's tempting to put somebody else in the Win slot for Leicester, but Mahrez is in player-of-the-season form at the moment and is delivering stellar fantasy points in all formats. Must-have.
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Out: Joe Flanagan, Daniel Sturridge
Doubt: Jordan Henderson, Danny Ings (selection)
In: Philippe Coutinho, Mamadou Sakho
Win: Philippe Coutinho
A victory is much-needed for Liverpool, and Coutinho's return comes at a perfect time for the Reds. With no Luis Suarez to torment the Norwich defense, the little Brazilian will have to work his magic instead. I think he'll do just that.
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Out: Fabian Delph, Gael Clichy, Vincent Kompany, Samir Nasri, Pablo Zabaleta
Doubt: Jesus Navas (selection)
In: Nicolas Otamendi, Kevin De Bruyne
Win: David SIlva
West Ham have proven to be difficult opponents on the road this season, but Silva's got the quality to pick apart any defense. If he's on his game, expect a victory for Manchester City. If not, we could see another shock this weekend.
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Out: Phil Jones, Luke Shaw
Doubt: Marouane Fellaini (selection)
In: Marcos Rojo, Wayne Rooney
Win: Juan Mata (hunch)
Something about this match screams Juan Mata to me. I don't know if that's because Matt Targett has struggled against good dribblers this season or just that United haven't had many more consistent attacking options, but I think the little Spaniard will play a big part in what should be another Red Devils victory.
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Out: Aleksandar Mitrovic (suspended), Paul Dummett, Steven Taylor, Cheick Tiote
Doubt: Papiss Cisse (selection)
In: Ayoze Perez (maybe)
Win: Daryl Janmaat
Watford haven't been scoring many goals, so a clean sheet is a distinct possibility. Add Janmaat's attacking contributions to that potential and you've got a player who could get back to producing the big numbers that made him such a popular option last season.
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Out: Youssuf Mulubu, Gary Hooper, Andre Wisdom (ineligible)
Doubt: Graham Dorrans (selection)
In: Steven Whittaker
Win: Nathan Redmond
Liverpool's struggles down the left flank have been well documented at this point, and Redmond will certainly pose a challenge to whoever lines up along his side. The youngster has loads of pace and an eye for goal, and could build on an impressive start this time out.
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Out: Ryan Bertrand, Jordy Clasie, Fraser Forster, Florin Gardos
Doubt: Gaston Ramirez, Steven Caulker (selection), James Ward-Prowse (rotation)
In: Virgil van Dijk, Sadio Mane, Jay Rodriguez
Win: Sadio Mane
After being given the week off last match, Mane will be well rested and ready to go against summertime suitors United. The players in the attacking band for the Saints are all capable of scoring, but I think we'll see another all-action performance from the Senegalese midfielder lead the way.
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Out: Ryan Shawcross, Charlie Adam (suspended), Ibrahim Afellay (suspended)
Doubt: Mame Biram Diouf, Phil Bardsley (rotation)
In: Glen Johnson, Bojan Krkic
Win: Xherdan Shaqiri
Now that Bojan is back in contention, we should start seeing Shaqiri afforded a bit more time on the ball as defenders have to worry about another dangerous attacker. I think we'll see the former Inter Milan man get on the scoresheet against a porous Leicester defense.
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Out: Duncan Watmore, Adam Matthews
Doubt: Adam Johnson
In: N/A
Win: Fabio Borini (hunch)
After a poor outing in his first match back with the Black Cats, I think we'll see the Italian striker starting to get back to his best. With another full week of training under his belt, he should be much sharper, and I have a sneaking suspicion he'll pop up with a timely goal this weekend.
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Out: N/A
Doubt: Jack Cork, Wayne Routledge (both rotation)
In: Ki Sung-yeung, Jefferson Montero
Win: Gylfi Sigurdsson (hunch)
We've seen Ayew, Montero and Gomis running the show for Swansea this season, but what about old blog favorite Gylfi Sigurdsson? He's surely still got all the talent and potential, and I think that comes to the fore against an Everton side that tends to give up a decent amount of set pieces.
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Out: Nabil Bentaleb
Doubt: Mousa Dembele, Eric Dier, Ryan Mason, Christian Eriksen
In: Dele Alli, Tom Carroll
Win: Son Heung-min
Spurs have looked dreadful without Christian Eriksen pulling the strings, but their new South Korean attacker put in a man-of-the-match performance in the Europa League on Thursday and looks to be settling into his new role nicely. If Eriksen remains out, look to Son to generate the attacking play for Spurs.
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Out: Valon Behrami (suspended), Miguel Britos (suspended)
Doubt: Mamadou Oulare
In: Ben Watson
Win: Craig Cathcart
Watford look to have a Premier League quality defensive setup, and Cathcart is at the helm. If only they could score more goals, we might be looking at them much differently.
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Out: Ben Foster
Doubt: Jonny Evans, Callum McManaman (rotation)
In: Jonas Olsson (maybe), Saido Berahino (maybe)
Win: Salomon Rondon
The Venezuelan striker has gotten off to a good start in the Premier League, but could soon face competition from Saido Berahino for his starting spot. He'll need to continue putting in solid performances to convince Tony Pulis he'll have to play two strikers if he wants to get Berahino on the pitch. A goal against Villa will go a long way to proving that point.
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Out: Angelo Ogbonna, Alex Song, Enner Valencia
Doubt: Pedro Obiang, Mauro Zarate, Darren Randolph (selection), Manuel Lanzini (rotation)
In: Adrian, James Tomkins, Victor Moses
Win: Dimitri Payet
Given his form since his transfer to West London, you have to like Payet's chances against any side, even the mighty Citizens. We'll see how far his quality reaches this weekend, but if anyone is going to trouble Joe Hart's goal, Payet seems like the man to do it.