We get started this round with an early match between Tottenham Hotspur and Sunderland, and momentum at the moment favors the Black Cats. Jermain Defoe scored an excellent hat-trick against Swansea City midweek and faces one of his many former employers when he and the rest of Sam Allardyce's charges travel to North London.
Spurs are coming off a last-minute loss to Leicester City in week 21, and will be eager to put themselves back in the title hunt with a victory at White Hart Lane. Harry Kane, Christian Eriksen and Dele Alli will be in plenty of fantasy squads this weekend given their strong returns so far this season.
Following the early match today, we'll see Southampton hosting West Bromwich Albion, West Ham United traveling to take on Newcastle, Manchester City facing off against Crystal Palace, a crucial clash between Chelsea and Everton, and a potential relegation six-pointer as AFC Bournemouth host Norwich City. Aston Villa will look to make it two wins on the bounce against league leaders Leicester in the late match to close out the day.
Here are the teams I'll be running out for Week 22:
Fuchs, Kolarov, Cissokho
Cabaye, Payet, KDB, Eriksen
Aguero, Kane, Valencia
Fuchs, Kolarov, Rose, Smith
Payet, KDB, Eriksen, Mahrez
Simpson, Francis, Kolarov
Payet, Ozil, Mahrez, Willian, Stanislas
Lukaku, Kane ©
B: Hennessey, Giroud, Evans, Clyne
How have your teams shaped up? Good luck this week as always, and let's chat!