The main news for Arsene Wnger's visit to Sunderland is that Theo Walcott will under go the dreaded late fitness test because of a minor hamstring problem. Lucas Perez is confirmed out for up to six weeks after limping off against Reading midweek. Santi Cazorla is a doubt and will be assessed before Arsenal travel while Nacho Monreal is also a minor doubt, but is likely to be included. Aaron Ramsey is likely to be named among the substitutes as the Welshman accrues match fitness after a lengthy injury lay off. Granit Xhaka remains suspended.
Andrew Surman has trained this week despite recently having an illness and Junior Stanislas will be assessed after withdrawing from the Spurs match with a calf strain. Brad Smith remains injured.
Steven Defour is still a major doubt for the trip to Old Trafford nursing a hamstring injury. Geroge Boyd has returned for training and may be included by Eddie Howe after missing the win over Everton.
Branislav Ivanovic, Cesc Fabregas, and John Obi Mikel are all doubts due to muscle injury. Kurt Zouma is closer to a return after featuring for the youth squad. Willian played 90min midweek and could be replaced by Pedro on the right wing for the trip to Southampton.
Scott Dann is likely to be recalled for the visit of Liverpool after an injury lay off. Jason Puncheon is a doubt due to a calf problem and will be assessed.
Bryan Oviedo seems likely to retain his left back role as Leighton Baines continues to recover from a hamstring injury. Otherwise Ronald Koeman will have some decisions to make regarding the Toffees recent loss to Burnley, but has most of his squad available.
Robert Snodgrass is out for up to four weeks, representing a major blow to manager Mike Phelan. Adama Dimonade is facing a 3 match suspension with Hull City having until this evening to contest the decision. Andrew Robertson remains out with a calf injury.
Claudio Ranieri has most of his squad available for the trip to White Heart Lane, but will have to decide on his strike force with Shinji Okazaki pushing for inclusion.
Jurgen Klopp will decide if Georgino Wijnaldum will return to the starting line up after playing 90min midweek, but the German will have a nearly full squad to choose from for the visit to Crystal Palace.
Kevin De Bruyne is a doubt with a calf injury and will need to be assessed before traveling to West Brom. Pablo Zabaleta is also a doubt following a knock and will be assessed as well. Vincent Kompany played only 45min midweek but seems unlikely to start.
Eric Bailly is likely to be out up to two months with a knee injury, a huge blow for Jose Mourinho's side. Chris Smalling is a slight doubt with a knock and Marcus Rashford had a cramp complaint but is likely to be included. Wayne Rooney, unlikely to start anyway, is also a doubt due to a thigh problem.
Calum Chambers returns after being ineligible to play against his parent club, Arsenal. Grant Leadbitter is edging closer to a return but still may need to be eased back.
Ryan Bertrand, Matt Targett and Cedric Soares are major doubts ahead of the home clash with Chelsea. Jay Rodriguez is a doubt following a concussion.
Geoff Cameron is a doubt for the visit of Swansea City. Phil Bardlsey is a doubt with the potential be allowed compassionate leave after a death in the family. Jakob Haugaard remains out.
Jason Denayer and Lee Cattermole are closer to a first team return but probably not for this coming week against Arsenal. Otherwise no new injury concerns for David Moyes as the Black Cats seek their first win of the season.
Jefferson Montero has returned to full training but may not be immediately available following an ankle injury. Bob Bradley may retain Gylfi Sigurdsson as the "false 9" as the American looks for his first win in his Premier League career.
Toby Alderweild is still a major doubt with Eric Dier likely to remain at center half. Moussa Sissoko is suspended for 3 matches after Spurs accepted a violent conduct charge. Son looks poised to lead the line as Vincent Janssen played 90min midweek.
Daryl Janmaat is fit again following an injury lay off, otherwise Watford have no new injury concerns.
Claudio Yacob is suspended for the visit of Manchester City but Jonny Evans returns from his one match suspension. James McClean suffered a gash against Liverpool but is likely to be available.
Andre Ayew has returned from injury and featured midweek, although it will remain to be seen if he will start this week. Slaven Bilic has no fresh injury concerns.
Good luck in your Week 10 selections!