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Out: Fantasy-relevant players who have been confirmed out for the week, either through injury or suspension
Doubt: Players facing the dreaded fitness test, rotation concerns and those who are out of form/favor
In: The likeliest replacements for the Outs & Doubts or those returning from injury
Win: Fantasy player to watch / my hunch pick of the week
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Out: Jack Wilshere, Santi Cazorla, Tomas Rosicky, Danny Welbeck
Doubt: N/A
In: Per Mertesacker, Francis Coquelin
Win: Alexis Sanchez
The returns of Mertesacker and Coquelin should help sure up that defensive line and take some of the pressure off of Cech in goal. The Gunner attacking quartet of Walcott, Ozil, Giroud and Sanchez will test The Cherries.
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Out: Jordan Amavi, Adama Traore, Libor Kozak, Jordan Ayew (suspension)
Doubt: Alan Hutton, Carlos Sanchez, Ashley Westwood
In: Gabriel Agbonlahor
Win: Gabriel Agbonlahor
Villa losses Jordan Ayew to yet another suspension after an ill-intended elbow landed him a red card at midweek. With lack of depth at striker, Agbonlahor (newly back from injury himself) figures to slot in the number nine role.
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Out: Callum Wilson, Max Gradel, Tyrone Mings
Doubt: Junior Stanislas
In: N/A
Win: N/A
There are no winners as the Cherries take on Arsenal. The squad figures to be unchanged and over-matched.
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Out: Loic Remy, Alexandre Pato, Radamel Falcao
Doubt: Pedro
In: Eden Hazard
Win: Eden Hazard
It's hard not argue Hazard getting back to the Starting XI isn't a win in itself for the Belgian. The matchup against Manchester United is less than favorable, but recent evidence may suggest more of an up-and-down affair than the scoreless draw between these two in the reverse fixture.
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Out: Yannick Bolasie, Bakary Sako, Joe Ledley, James McArthur, Jason Puncheon, Connor Wickham (suspended)
Doubt: Yohan Cabaye
In: Jordon Mutch, Dwight Gayle
Win: Wilfried Zaha
With all of the injuries and poor play out of Crystal Palace in recent weeks, it's hard to find any positive lights. The added responsibility on Zaha to produce has equated to a goal and assist in his last two matches across all competitions.
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Out: Tony Hibbert, Tyias Browning
Doubt: Muhamed Besic, Tim Howard, Romelu Lukaku (questionable), Oumar Niasse, John Stones
In: Arouna Kone (if Lukaku misses), Gerard Deulofeu
Win: Joel Robles
With so much uncertainty in the outfield, Robles seems a fairly strong favorite to start between the sticks. Coming off a clean sheet at midweek, Robles could soon spell the end of American Howard's tenure as the Everton keeper.
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Out: Jeffrey Schlupp
Doubt: Daniel Amartey
In: N/A
Win: Kasper Schmeichel
Schmeichel's form has been nearly unpenetrable with consecutive clean sheets while allowing just one goal since the calendar turned to 2016. The matchup at the Ethiad will test that form.
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Out: Philippe Coutinho, Divock Origi, Joe Gomez, Jordan Rossiter, Danny Ings, Martin Skrtel
Doubt: Joe Allen
In: Jordan Ibe
Win: Nathaniel Clyne
Facing Sunderland at home is a must result for Liverpool. Clyne's presence at right-back promotes contributions both offensively and defensively in a favorable home match-up against the Black Cats.
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Out: Wilfried Bony, Kevin De Bruyne, Vincent Kompany, Eliaquim Mangala, Samir Nasri, Jesus Navas
Doubt: Delph
In: Raheem Sterling
Win: Sterling
With an injury to Navas a sub-par display from Iheanacho at midweek, Sterling's return to the Starting XI seems eminent.
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Out: Luke Shaw, Marcos Rojo, Antonio Valencia, Bastian Schweinsteiger, Ashley Young, Phil Jones
Doubt: N/A
In: N/A
Win: Anthony Martial
The return to form for Wayne Rooney is a deserved headline, but visually 20-year-old Martial looks to be a budding star. Martial comes into this key match against Chelsea off a goal and assist at midweek.
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Out: Tim Krul, Massadio Haidara, Curtis Good, Gabriel Obertan, Papiss Cisse, Siem de Jong, Paul Dummett, Chancel Mbembam Jamaal Lascelles (suspension)
Doubt:
In: Rolando Aarons, Steven Taylor
Win: Jonjo Shelvey
When half of your squad is out to injury, it's hard to say anybody wins. That said, Shelvey's new arrival to the squad has looked promising. He will play a key role delivering the ball up field going foward.
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Out: N/A
Doubt: Robbie Brady, Dorrans
In: Steven Naismith
Win: Steven Naismith
The Canaries will look to bring Naismith into the number ten role, and the former Everton man should provide a boost to the offense as Norwich looks to stay above the relegation line in this key match against league bottom Villa.
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Out: Florin Gardos, Jay Rodriguez, Matt Targett
Doubt: Steven Davis
In: Charlie Austin
Win: Charlie Austin
The former QPR man has already scored in his eleven minutes of field time for the Saints. He's a big time goal scorer, and playing within an offense as strong as Southampton's will only help deliver him more goal scoring opportunities.
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Out: Shay Given, Charlie Adam, Marc Wilson, Geoff Cameron, Ryan Shawcross
Doubt: Phillipp Wollscheid
In: Giannelli Imbula
Win: Xherdan Shaqiri
Seemingly every match (the midweek clean sheet being an exception) Everton plays results in lots of goals. I name Shaqiri due to the great probability he features as much as anything. The Stoke attacking squadron still remains very much in flux.
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Out: Sebastian Larsson
Doubt: Jeremain Lens, Yann M'Villa
In: Wahbi Khazri
Win:Wahbi Khazri
Welcome Whabi Khazri, the new Sunderland winger should bring a strong dose of much needed pacey offense to the Black Cat attack.
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Out: Ki Sung-yeung
Doubt: N/A
In: Alberto Paloschi
Win: Alberto Paloschi
A much needed new striker looks to be welcomed to the Swans in Italian Paloschi. Prior to being transferred, he had 8 goals in Serie A and a similar contribution would be welcomed to the goal poor Swansea side.
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Out: Jan Vertonghen, Clinton N'Jie
Doubt: Dele Alli, Ryan Mason
In: N/A
Win: Christian Eriksen
I could've just as easily slotted in Harry Kane, but the goal scoring exploits of Kane and Alli have seemingly left Eriksen under the radar. He's having a good season in his own right delivering a lot of key passes while still holding free kick and corner taking duty.
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Out: N/A
Doubt: Miguel Britos, Etienne Capoue
In: Nathan Ake
Win: Odion Ighalo
Ighalo hasn't been as exceptional of late, but his prolific scoring ability can raise it's head at anytime against anyone.
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Out: James Morrison, Callum McManaman, Chris Brunt, Jonny Evans
Doubt: N/A
In: N/A
Win: James McClean
As long as he isn't getting carded for inappropriate behavior, McClean has been an extremely potent offensive threat. A weak Magpie defense awaits.
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Out: Sam Byran, Manuel Lanzini, Diafra Sakho
Doubt: Angel Ogbonna, Andy Caroll
In: N/A
Win: Michail Antonio
Despite accolades for fellow attackers Valencia and Payet, Antonio has contributed to a goal (whether it be via goal or assist) in five of his last seven matches.
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Has this injury news affected your plans for this weekend? Are there any slight doubts you're still considering for your team? Share your thoughts and questions in the comments!