Out: Fantasy-relevant players who have been confirmed out for the week, either through injury or suspension
Doubt: Players facing the dreaded fitness test, rotation concerns and those who are out of form/favor
In: The likeliest replacements for the Outs & Doubts or those returning from injury
Win: Fantasy player to watch / my hunch pick of the week
Out: Santi Cazorla, Petr Cech, Carl Jenkinson, Laurent Koscielny, Alex Oxlade-Chamberlain, Thomas Rosicky
Doubt: Jack Wilshere
In: David Ospina
Win: Olivier Giroud
Since losing Vertonghen, the once-dominant Spurs defense has been looking very shaky. Giroud should be able to get some chances in a very contentious North London derby.
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Out: Jordan Amavi, Jack Grealish, Carlos Sanchez, Adama Traore
Doubt: Libor Kozak
In: N/A
Win: Jordan Ayew
Back and healthy again, he should be able to cause City's defense problems. While Kompany is back and healthy, this Citizen defense is still trying to figure out what is wrong, and Ayew won't get them many chances to relax.
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Out: Tyrone Mings, Junior Stanislas, Callum Wilson
Doubt: Harry Arter, Joshua King
In: Max Gradel
Win: Matt Ritchie
No team has had a lower amount of passes in the opposition half (54%) than Newcastle. This means Bournemouth's active winger should get plenty of possession in Newcastle's end of the pitch, plenty of corner kicks, and a few chances to connected with Benik Afobe for a goal.
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Out: Radamel Falcao, Kurt Zouma, John Terry, Pedro
Doubt: Alexandre Pato (fitness), Kenedy
In: Baba Rahman, Willian, John Obi Mikel
Win: Willian
Do you really need to be told why Willian is the best play here? I didn't think so. You're a savvy manager. The man does it all. Takes corners. Wins free kicks. Scores on free kicks. Finds Diego Costa's forehead and feet. Play him.
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Out: James McArthur, Jason Puncheon
Doubt: Wayne Hennessey, Connor Wickham, Martin Kelly (rotation)
In: Pape Souare, Julian Speroni, Emmanuel Adebayor (maybe)
Win: Yannick Bolasie
This Palace team is so much different with him in the lineup. Even Jurgen Klopp said he is their biggest worry heading into this match. He also has been terrific in his last two matches against Liverpool, with the technical ability to hurt them in defense.
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Out: Tyias Browning
Doubt: Bryan Oviedo, Muhamed Besic, Tom Cleverley, Darron Gibson, Ramiro Funes Mori (rotation)
In: Leighton Baines (maybe), John Stones (maybe)
Win: Romelu Lukaku
With an injury-hit Hammers back line to play against, the Belgian striker will have plenty of opportunities to try to chase down Vardy for the leading scorer title. If you can manage to fit him in with Kun Aguero, you'll be in good shape this week. Unless he trolls us.
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Out: Ritchie De Laet, Matty James, Andrej Kramaric
Doubt: Andy King (rotation)
In: N'Golo Kante
Win: Marc Albrighton
Jamie Vardy and Riyad Mahrez continue to disappoint based on the insanely high standards they set for themselves earlier in the season, but Albrighton has been picking up the slack with some excellent performances lately. His crossing ability makes him worthwhile in formats that reward accuracy, while he could always pop up with a goal or assist.
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Out: Lucas Leiva, Danny Ings, Joe Gomez
Doubt: Mamadou Sakho, Divock Origi (rotation), James Milner (rotation), Alberto Moreno (selection)
In: Daniel Sturridge, Philippe Coutinho, Martin Skrtel (maybe)
Win: Daniel Sturridge
After spending much of the season on the sidelines, Sturridge has shown flashes of his best form. Likely to earn a start this weekend, he'll link up with Roberto Firmino and Coutinho in the hopes of breaking the hoodoo against Palace.
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Out: Kevin De Bruyne, Fabian Delph, Samir Nasri
Doubt: Fernando, Gael Clichy, Jesus Navas (all rotation)
In: David Silva, Yaya Toure, Aleksandar Kolarov
Win: Sergio Aguero
There's not really much explanation needed here. When fit, Aguero's the best striker in the league. Taking on bottom-of-the-table Villa is just icing on the cake.
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Out: Wayne Rooney, Bastian Schweinsteiger, Ashley Young, Antonio Valencia
Doubt: Chris Smalling, Cameron Borthwick-Jackson, Phil Jones, Marouane Fellaini, Memphis Depay (rotation), Guillermo Varela (rotation)
In: Matteo Darmian (maybe), Anthony Martial, Michael Carrick
Win: Anthony Martial
The youngster should return, either at left wing or striker, though given the form of Marcus Rashford it seems likelier Martial will replace Memphis Depay. Either way, the Frenchman is another player who immediately improves United's chances for attacking contributions, and should have plenty of chances against West Brom.
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Out: Fabricio Coloccini, Chancel Mbemba, Tim Krul
Doubt: Papiss Cisse, Yoan Gouffran
In: Andros Townsend (maybe), Ayoze Perez (maybe)
Win: Georginio Wijnaldum
Wijnaldum's record at home speaks for itself at this point in the season. The Dutchman loves playing in front of his fans, and could add to his tally against the Cherries.
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Out: Alexander Tettey, Andre Wisdom
Doubt: Sebastian Bassong, Wes Hoolahan (rotation), Cameron Jerome (rotation)
In: Gary O'Neil, Steven Naismith, Diumerci M'bokani
Win: Nathan Redmond
With some slight doubts over Robbie Brady, who should start but who chipped two teeth midweek, Redmond is the midfielder of choice. His goal against Chelsea should see him keep his place in the starting lineup, and he'll be eager to show why he deserves to be the starter.
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Out: Victor Wanyama (susp), Charlie Austin, Shane Long
Doubt:
In: Graziano Pelle, Sadio Mane, Dusan Tadic (maybe), Jordy Clasie (maybe)
Win: Virgil van Dijk
Ronald Koeman continues to confound fantasy managers with his constant tinkering, but VVD has been a consistent starter at the center back position. His goal threat adds to his appeal as the Saints attempt to rediscover their defensive dominance at home.
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Out: Phil Bardsley, Glen Johnson, Charlie Adam
Doubt: Ryan Shawcross
In: Geoff Cameron
Win: Xherdan Shaqiri
The Swiss midfielder has shown his best form over the last two matches and will likely line up against Baba Rahman this weekend. Nothing against the Chelsea left back, but you have to like Shaqiri's chances to make it a hat-trick of strong performances.
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Out: Lee Cattermole, Jeremain Lens, Duncan Watmore
Doubt: Jan Kirchhoff, John O'Shea
In: Younes Kaboul (maybe)
Win: Jermain Defoe
The veteran striker is one of those ever-reliable players for a team verging on relegation, and this is the time of year he turns it on. Sunderland may be facing the Saints at the right time after they've conceded multiple goals lately.
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Out: N/A
Doubt: Leroy Fer, Kyle Naughton, Jordi Amat, Stephen Kingsley, Ki Sung-yueng (all rotation)
In: Alberto Paloschi, Gylfi Sigurdsson, Leon Britton, Angel Rangel, Neil Taylor, Federico Fernandez
Win: Gylfi Sigurdsson
The Icelandic midfielder will return to the starting lineup and will resume set piece duty against a piecemeal Norwich side. He played a major role in the victory over Arsenal and will be high on confidence against a weaker team.
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Out: Jan Vertonghen, Clinton N'Jie
Doubt: Ben Davies, Kieran Trippier, Ryan Mason (all rotation)
In: Dele Alli, Danny Rose, Kyle Walker, Mousa Dembele (maybe)
Win: Harry Kane
This will be a huge match for the title challengers, and Kane will fancy his chances against David Ospina. Expect plenty of shots from the England international.
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Out: N/A
Doubt: Craig Cathcart, Jurado, Valon Behrami (rotation), Almen Abdi (rotation)
In: Nordin Amrabat, Nathan Ake, Mario Suarez (maybe)
Win: Heurelho Gomes
The former Spurs goalkeeper has been one of the most consistent keepers in the BPL this season and has racked up big save points on numerous occasions. Leicester are fighting for the title, but the Hornets are solid at home, particularly defensively, and Gomes will be a key man in this test.
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Out: Chris Brunt, Jonny Evans, James Morrison, Callum McManaman
Doubt: N/A
In: James Chester
Win: Craig Gardner
Gardner has been in excellent form since being restored to the starting lineup, and has taken up set piece duty with Chris Brunt ruled out. Expect him to have a positive impact on the game for the Baggies, regardless of result.
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Out: Sam Byram (susp), Winston Reid, James Collins, Joey O'Brien, James Tomkins, Victor Moses, Enner Valencia
Doubt: Pedro Obiang (rotation), Andy Carroll, Diafra Sakho
In: Reece Oxford, Alex Song (maybe)
Win: Manuel Lanzini
With so many defensive worries, it's tough to bet on the Hammers defenders this week. Additionally, Michail Antonio and Dimitry Payet will be playing out of position, so Lanzini seems like a good bet to rediscover some of his early-season form as a nice differential pick-up.