With the Red Devils and Saints set to face each other on a Friday evening, team news and press conference information is going to be slightly less reliable than usual for Sunday's slate of matches in Week 2. However, here's a rundown of what we know so far.
Chris Smalling and Paul Pogba are both fit and available for Jose Mourinho, though it's a possibility both could start from the bench after a strong opening day performance. In any case, Pogba is not ready to play 90 minutes. Henrikh Mkhitaryan remains somewhat short of match fitness as well.
Ryan Bertrand is the only confirmed absentee for Claude Puel's men, though there could be some rotation in central midfield with either Oriol Romeu or James Ward-Prowse potentially replaced by summer signing Pierre-Emile Hojbjerg.
Stoke v. Manchester City
Glen Johnson will remain sidelined, though should be in line for a return ahead of Week 3. Phil Bardsley will continue to deputise at right back. Jack Butland is also set to spend this match out of the squad, so Shay Given will remain in goal. Xherdan Shaqiri is a slight doubt with a knock, but should be fit to start. Joe Allen could make his Potters debut in place of Mame Biram Diouf.
Aleksandar Kolarov looks likely to drop out of the starting lineup to accommodate the return of Nicolas Otamendi, though there may not be any other adjustments to the squad that claimed victory in Week 1. Willy Caballero should continue ahead of Joe Hart in goal.
New signing Steven Defour could come straight into the starting lineup in central midfield, with David Jones completing a transfer to Sheffield Wednesday. Johann Berg Gudmundsson is pushing for a start and could replace either George Boyd or Scott Arfield in the starting lineup. Jon Flanagan is ineligible to face his parent club.
Sadio Mane is the biggest concern for Jurgen Klopp, and doesn't look likely to make the starting lineup after picking up a shoulder injury in training during the week. Alberto Moreno could be replaced by James Milner after a poor display against the Gunners, while Daniel Sturridge is fit again and could lead the line, though it is more likely we see Divock Origi from the start. Emre Can will be restored to the starting lineup at the expense of either Jordan Henderson or Georginio Wijnaldum.
Neil Taylor looks set to spend another week on the sidelines, which is good news for Stephen Kingsley owners. He'll continue at left back in the Welshman's absence. New record signing Borja Baston injured himself in record time after his arrival and will not make his debut against the Tigers. Gylfi Sigurdsson looks set to replace Leon Britton in the starting lineup for this one as well.
Mike Phelan thankfully has no new injury concerns and will almost certainly keep the faith with the same eleven who pulled off a huge upset over Leicester last weekend.
Hugo Lloris is the major absentee for Spurs after pulling up injured midway through last week's opener. Michel Vorm stepped in to replace the Frenchman, and will continue between the posts. Mousa Dembele remains suspended, so Victor Wanyama and Eric Dier should continue in the engine room. Vincent Janssen will be pushing for a start after impressing off the bench, though there are no clear options as to who he would replace.
With Mile Jedinak and Yannick Bolasie leaving the club, there are a few holes to fill in midfield. Yohan Cabaye should return to the starting lineup in central midfield, with Joe Ledley or Lee Chung-Yong joining him. Steve Mandanda could challenge Wayne Hennessey for a starting role in net. Connor Wickham looks safe for at least one more week, though Christian Benteke looks likely to arrive at the London club before the end of the transfer window.
Ben Watson is suspended after his red card last week, so Adlene Guedioura looks likely to continue in central midfield. There are likely no other changes to the starting lineup in this one.
Antonio Conte is also unlikely to switch things up following the late win over the Hammers in his first Premier League match. Cesc Fabregas could push for inclusion, but Oscar and Nemanja Matic both impressed last time out so he may have to settle for minutes off the bench.
No changes are expected for Tony Pulis' side following an impressive Week 1 victory.
Yannick Bolasie could face the Baggies for the second week running after joining the Toffees midweek, though he may have to settle for a substitute role as he settles in. Ashley Williams may also be ready for a start, with Mason Holgate the likeliest to drop to the bench.
Robert Huth returns from suspension and will likely slot straight back into the starting lineup in place of Luis Hernandez. Marc Albrighton and Shinji Okazaki could be in line for starts in place of Demarai Gray and Ahmed Musa, though it is unclear who Claudio Ranieri prefers at this stage. Nampalys Mendy could get his first start for the Foxes ahead of Andy King.
Laurent Koscielny looks likely to be restored to the starting lineup in place of Rob Holding, but Alex Iwobi and Aaron Ramsey are out for this one. Alex Oxlade-Chamberlain and Santi Cazorla are the likely candidates to replace them. Olivier Giroud and Mesut Ozil are most likely another week away from being fit to start.
Sunderland v. Middlesbrough
Jan Kirchoff isn't ready for a return to action just yet, so John O'Shea or Paddy McNair will get the nod in central midfield. Wahbi Khazri should be restored to the starting lineup, with Adnan Januzaj pushing Duncan Watmore for a place in the first team as well.
Marten De Roon is set for a spell on the sidelines after pulling up with a hamstring injury in Week 1. Adam Forshaw could replace him in central midfield. Otherwise, look for an unchanged lineup after impressive performances from the likes of Gaston Ramirez and Alvaro Negredo last time out.
Andre Ayew is a long-term casualty after picking up a thigh injury against Chelsea on Monday. Gokhan Tore looks likely to get the start in his place with Sofiane Feghouli still struggling with the knock that kept him out in week 1, though Slaven Bilic also has the option of pushing Michail Antonio into midfield and giving Sam Byram a start at right back. Dimitri Payet should also be restored to the starting lineup at the expense of Enner Valencia.
While there aren't any new injury concerns for the Cherries, rotation could come into play for a number of players, particularly in the attacking positions. Benik Afobe and Max Gradel look the most likely to push for starting roles up top, with Nathan Ake also potentially included in place of Lewis Cook.
As news comes in ahead of the deadline, please share in the comments to help your fellow fantasy managers. Remember to save your teams before this evening's match! Good luck!