Olivier Giroud is the only major doubt for the match with Chelsea after sustaining a toe injury. The Frenchman will be assessed before the kick off in the dreaded late fitness test. Per Mertesacker, Aaron Ramsey, and Danny Welbeck all remain sidelined.
Ryan Fraser is doubtful for Eddie Howe's side, otherwise the Cherries have no other injury concerns.
Andre Gray will start the first of his four match suspension for homophobic comments made on social media stemming from 2012. However, Sean Dyche should have no other worries for the visit of Watford at Turf Moor.
John Terry is still sidelined with an ankle injury meaning David Luiz will retain his central defensive starting role. Cesc Fabregas is surely running out of ideas on how to impress new Chelsea boss Antonio Conte, with the midfielder showing his quality by scoring a brace in extra time midweek. Kurt Zouma remains a long term absentee.
Alan Pardew will be missing Scott Dann for the trip to Sunderland after injuring his hamstring midweek. Loic Remy remains sidelined.
Romelu Lukaku is a slight doubt after Ronald Koeman revealed the striker trained on his own Thursday. The Belgian is likely to link back up with teammates on Friday to be assessed but is expected to be fit to face Bournemouth.
Jake Livermore is back after serving a one match suspension midweek as Mike Phelan has no new injury problems for the trip to Anfield.
Kasper Schmeichel has recovered from his concussion injury but Claudio Ranieri stated the keeper has a slight muscular problem and will be assessed. Marcin Wasilewski is suspended for the current Champions.
Jugen Klopp has revealed Daniel Sturridge is a slight doubt after picking up a knock against Chelsea and will be assessed. Mamaduo Sako and Joe Gomez continue their path to full fitness.
Nolito will be suspended for the trip to Swansea as David Silva remains a doubt. Sergio Aguero will be welcomed back from suspension by Pep Guardiola and should slot straight into the side at the expense of Kelechi Iheanacho.
Anthony Martial is sidelined for the clash against Leicester City at Old Trafford. Luke Shaw and Henrikh Mkhitaryan will be in contention with the former most likely to start.
Cristhian Stuani and Jordan Rhodes have been passed fit for the visit of Tottenham with the former more likely to start. No other injury concerns of note.
No fresh injury problems for the trip to West Ham, but Charlie Austin will be pushing for a recall after only playing 57 minutes midweek.
Xherdan Shaqiri has returned to full training and will be in contention for the home clash against West Brom. Jakob Haugaard is a doubt with an ankle problem.
David Moyes has revealed that Wahbi Khazri is a doubt due to illness but is expected to have Jermain Defoe and Patrick van Aanholt for the home match against Crystal Palace.
Francesco Guidolin has no fresh injury concerns for the visit of Manchester City.
The major news is that Harry kane will be sidelined for a number of weeks after an ugly ankle injury sustained against Sunderland. Eric Dier Mousa Dembele are slight doubts but expected to feature. Danny Rose is close to a return but will be assessed before the match.
Daryl Janmaat has been ruled out for the next four to six weeks with a shoulder injury. Jose Holebas is a slight doubt for the trip to Burnley on Monday.
Tony Pulis is likely to name an unchanged side for the visit to Stoke City with no fresh injury concerns.
Winston Reid should be back in contention after missing the last defeat to West Brom through injury. Alvaro Arbeloa could start at right back after completing 90 minutes midweek. Slaven Bilic has no other major doubts for the home match against Southampton.
Good luck setting your teams for the Week 6 deadline!